USPTO Patents Application 10561839

IN THE

UNITED STATES PATENT AND

TRADEMARK OFFICE

In re Applicant:

Serial "No.:

Filed:

For:

Examiner:

Mordeehai DEUTSCHE

10/561,839

June 5, 2006

a Materials For Constructing Cell-Chips,
improved Material (to ProcesS ed
Cell-Chip Cover^ C nCh P

Cell-Chips And Uses i«
Not Yet Assigned

§

§

§
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§

§

§

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§

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Group Art Unit: 1744

Attorney
Docket: 30024

SUPPLFJvlEKrAL

. t to ^ e patentability

„ ■ a PTO Form .«» -ch Us. citafions »hich ma^n ^ ^
Enclosed >s a PTO ^ e „ closed are cop b

a „a - <he --^1, of „e defined in 3. CFR ,56.

These are submitted ,n comphan ^ ^

— — ° nSOf0ff ' C dI „«.*..——*-

^Suppient^Morrnationmseiosnre^ ^ ^ ^ „ ^ tc , *.

as . dentin tha, a search h, -
examination of this application does no, exts,

Respectfully submitted

tepeetfullysuDmu« u , ,

MartinD.Moynihan
Registration No. 40,338

Dated. September 26, 2006

Under the Paperwork Reduction Act of 1995, no pen

PTO/SB/08a (08-03)
Approved for use through 07/3 1/2006. OMB 065 1 -003 1
U.S.Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
collection of information unless it contains a valid OMB control number.

Substitute for form 1449A/P

SUPPLEMENTAL INFORMATION
DISCLOSURE
STATEMENT BY APPLICANT

(use as many sheets as necessary)

Application Number

Filing Date

First Named Inventor

Art Unit

Examiner Name

Complete if Known

10/561,839

June 05, 2006

Mordechai DEUTSCH et al

1744

Not yet Assigned

Sheet

1

of

Attorney Docket Number

30024

U.S. PATENT DOCUMENTS

Examiner
Initials*

No. 1

Document Number

\l u rt _- • j /-"_j^2 (if known)

N umber- K.ind Code

Publication Date
MM-DD-YYYY

Name of Patentee or
Applicant of Cited Document

Pages, Columns, Lines, Where
Relevant Passages or Relevant
Figures Appear

03-07-1 995

North Ir et al

1 i Vl 111 Jl . n_ I CI 1 »

2

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1 9-17-9009

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12-29-1998

Stabile et al

5

US-4 894 343

01-16-1990

W 1 1 V7 I J J \J

Tanaka et al

5

US-5 905 03 1

05-1 8-1999

v/ V \J 17 7 7

KTnvlen et al

7

I fS-4 799 949

03-08-1 988

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12-21-1993

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03-94-9005

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Walt et al

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19

US-5,059,266

10-22-1991

Yamane et al.

20

US-5,204,055

04-20-1993

Sachs etal.

21

US-6,046,426

04-04-2000

Jeantette et al.

22

US-6,066,285

05-23-2000

Kumar

23

US-6,1 17,612

09-12-2000

Halloran et al.

24

US-6,206,672

03-27-2001

Grenda

25

US-6,228,437

05-08-2001

Schmidt

26

US-6,238,614

05-29-2001

Yang et al.

27

US-6,329,195

12-11-2001

Pfaller

28

US-6,333,192

12-25-2001

Petitte et al.

29

US-6,338,964

01-15-2002

Matanguihan et al.

30

US-6,342,384

01-29-2002

Chung et al.

31

US-6,344,354

02-05-2002

Webster et al.

32

US-6,372,494

04-16-2002

Naughton et al.

33

US-6,376,148

04-23-2002

Liu et al.

34

US-6,378,527

04-30-2002

Hungerford et al.

35

US-6,383,810

05-07-2002

Fike et al.

36

US-6,403,369

06-11-2002

Wood

EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
considered. Include copy of copy of this form with next communication to applicant. 1 Applicant's unique citation designation number (optional). 2 See Kinds Codes
of USPTO Patent Documents at www.usDto.Qov or MPEP 901 .04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3).
4 For Japanese patent documents, the indication of the year of the reign of the Emperor must precede the serial number of the patent document. 5 Kind of document
by the appropriate symbols as indicated on the document under WIPO Standard ST. 16 if possible. 6 Applicant is to place a check mark here if English language
Translation is attached.

This collection of information is required by 37 CFR 1.97 and 1 .98. The information is required to obtain or retain a benefit by the public which is to file (and by the
USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. this collection is estimated to take 2 hours to complete, including
gathering, preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount
of time you require to complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, U.S. Patent and Trademark Office,
U.S. Department of commerce, P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS.

PTO/SB/08a (08-03)
Approved for use through 07/31/2006. OMB 0651-0031
U.S.Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE

Substitute for fnrm 144QA/PTO
ott TTT5TT5H 11? l^/fnC 1 MTT A IT TT TT7/T>kTn> f\A\ A IP TT ^0\T\T

b U Fir JLJk JVli JUr 1^1 11 AJL IrN Jb OKJVll A 1 HJJM
DISCLOSURE
STATEMENT BY APPLICANT

(use as many sheets as necessary)

Complete if Known

Annliratinn \Iiimhpr

i \jf jo i ,oj y

Filing Date

June 05, 2006

First Named Inventor

Mordechai DEUTSCH et al

Art Unit

1744

Examiner Name

Not yet Assigned

Sheet 2 of 5

Attorney Docket Number

30024

U.S. PATENT DOCUMENTS

Examiner
Initials*

Cite
No. 1

Document Number

Publication Date
MM-DD-YYYY

Name of Patentee or
Applicant of Cited Document

Pages, Columns, Lines, Where
Relevant Passages or Relevant
Figures Appear

Number-Kind Code 2 (if knmw,)

3 /

TIC >1 1 A TAO

Uo-6,4 10,309

r\/z oc onno

06-25-2002

Barbera- Guillem et al.

Jo

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r\ ~r onno

07-02-2002

Morris et aL

39

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07-02-2002

Field

40

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US-6,455,3 10

r\r\ o /i onrvo

09-24-2002

Barbera-Guillem et aL

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1 0-1 5-2002

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43

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10-22-2002

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49

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01-28-2003

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03-04-2003

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04-29-2003

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05-27-2003

van Loon et al.

53

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07-08-2003

Aoasolo et al.

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54

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07-08-2003

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I TC ^ ^Q'J 1 /in
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riela

56

US-6,610,516

08-26-2003

Andersen et al.

57

US-6,627,426

09-30-2003

Biddle et al.

58

US-6,635,448

10-21-2003

Bucciarelli et al.

59

US-6,642,050

11-14-2003

Goto et al.

60

US-6,649,408

11-18-2003

Bailey et al.

61

US-6,667,034

12-23-2003

Palsson et al.

62

US-6,670,180

12-30-2003

Block

63

US-6,670,184

12-30-2003

Chiarello et al.

64

US-6,673,591

01-06-2004

Lau

65

US-6,686,190

02-03-2004

Lau

66

US-6,689,594

02-10-2004

Hanni et al.

67

US-6,692,961

02-17-2004

Judd et al.

68

US-6,632,619

10-14-2003

Harrison et al.

69

US-2002/0106715

08-08-2002

Huberman et al.

70

US-5,707,869

01-13-1998

Wolf et al.

71

US-2002/0 189374

12-19-2002

DeSilets et al.

EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
considered. Include copy of copy of this form with next communication to applicant. Applicant's unique citation designation number (optional). 2 See Kinds Codes
of 0SPTO Patent Documents at www.uspto.gov or MPEP 901 .04. 3 Enter Office that issued the document, by the two-letter code (W1PO Standard ST. 3).
4 For Japanese patent documents, the indication of the year of the reign of the Emperor must precede the serial number of the patent document. 5 Kind of document
by the appropriate symbols as indicated on the document under WIPO Standard ST. 16 if possible. 8 Applicant is to place a check mark here if English language
Translation is attached.

This collection of information is required by 37 CFR 1.97 and 1 .98. The information is required to obtain or retain a benefit by the public which is to file (and by the
OSPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. this collection is estimated to take 2 hours to complete, including
gathering, preparing, and submitting the completed application form to the OSPTO. Time will vary depending upon the individual case. Any comments on the amount
of time you require to complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, O.S. Patent and Trademark Office,
U.S. Department of commerce, P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS.
SEND TO: Commissioner for Patents, P.O. Box 1450, Alexandria, VA 22313-1450

PTO/SB/08a (08-03)
Approved for use through 07/31/2006. OMB 0651-0031
U.S.Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.

Substitute for form 1 449A/PTO

SUPPLEMENTAL INFORMATION
DISCLOSURE
STATEMENT BY APPLICANT

(use as many sheets as necessary)

Complete if Known

Annlirfltinn Nnmh^r

lv/ j01,0j7

Filing Date

June 05, 2006

First Named Inventor

Mordechai DEUTSCH et al

Art Unit

1744

Examiner Name

Not yet Assigned

Sheet 3 of 5

Attorney Docket Number

30024

U.S. PATENT DOCUMENTS

Examiner
Initials*

Cite
No. 1

Document Number
Number-Kind Code 2(ifknovw,)

Publication Date
MM-DD-YYYY

Name of Patentee or
Applicant of Cited Document

Pages, Columns, Lines, Where
Relevant Passages or Relevant
Figures Appear

72

US-2003/0124716

07-03-2003

Hess et al.

73

US-5,650,323

07-22-1997

Root et al.

74

US-2003/0 104494

06-05-2003

Ravkin et al.

75

US-6,544,788

04-08-2003

Singh

76

US-6,660,501

12-09-2003

Field

FOREIGN PATENT DOCUMENTS

Examiner
Initials*

Cite
No. 1

Foreign Patent Documents

Publication Date
MM-DD-YYYY

Name of Patentee or
Applicant of Cited Document

Pages, Columns, Lines,
Where Relevant Passages
or Relevant Figures Appear

T

6

Country Code 5 * Number 4 " Kind Code 5 (if known)

77

PCT WO 99/47922

09-23-1999

Griffith et al.

78

JP 2005-102628

04-21-2005

Yamamura et al.

79

EP 1566635

08-24-2005

Muraguchi et al.

80

PCT WO 2005/069001

07-28-2005

Muraguchi et al.

81

PCT WO 2004/077009

09-10-2004

Deutsch

82

PCT WO 98/35223

08-13-1998

Kamentsky et al.

83

PCT WO 98/15356

04-16-1998

Gordon

84

PCT WO 99/45357

09-10-1999

Walt et al.

85

PCT WO 01/35071

05-17-2001

Braffet al.

86

PCT WO 03/056330

07-10-2003

Lassner et al.

87

PCT WO 02/26114

04-4-2002

Bitensky et al.

88

PCT WO 03/01 1451

02-13-2003

Wang et al.

89

PCT WO 02/063034

08-15-2002

Huberman et al.

90

PCT WO 01/88176

11-22-2001

Sunray et ah

91

PCT WO 2006/003664

01-12-2006

Deutsch et al.

92

PCT WO 2006/021959

02-2-2006

Deutsch et al.

Examiner Date
Signature Considered

•EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
considered. Include copy of copy of this form with next communication to applicant. 1 Applicant's unique citation designation number (optional). 2 See Kinds Codes
of USPTO Patent Documents at www.uspto.gov or MPEP 901 .04. 3 Enter Office that issued the document, by the two-letter code (WlPO Standard ST.3).
4 For Japanese patent documents, the indication of the year of the reign of the Emperor must precede the serial number of the patent document. 5 Kind of document
by the appropriate symbols as indicated on the document under WlPO Standard ST. 16 if possible. 6 Applicant Is to place a check mark here if English language
Translation is attached.

This collection of information is required by 37 CFR 1.97 and 1 .98. The information is required to obtain or retain a benefit by the public which is to file (and by the
USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. this collection is estimated to take 2 hours to complete, including
gathering, preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount
of time you require to complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, U.S. Patent and Trademark Office,
U.S. Department of commerce, P.O. Box1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS.
SEND TO: Commissioner for Patents, P.O. Box 1450, Alexandria, VA 22313-1450

PTO/SB/08b (08-03)
Approved for use through 06/30/2006. OMB 0651-0031
U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE

Ci ihotili it a fr\r fnrm 1/1/IQA/DTn

oUDSuiuie Tor form i4^yM/n i \j

SUPPLEMENTAL INFORMATION
DISCLOSURE
STATEMENT BY APPLICANT

(use as many sheets as necessary)

Complete if Known

Annliratinn T\IumV>f*r

10/561 839

Filing Date

June 05, 2006

First Named Inventor

Mordechai DEUTSCH et al

Group Art Unit

1744

Examiner Name

Not yet Assigned

Sheet 4 of 5

Attorney Docket Number

30024

OTHER PRIOR ART - NON PATENT LITERATURE DOCUMENTS

Examiner
Initials

Cite
No. 1

Include name of the author (in CAPITAL LETTERS), title of the article (when appropriate), title of the
item (book, magazine, journal, serial symposium, catalog, etc.) date, page(s), volume-issue number(s),
publisher, city and/or country where published.

Dolbeare "Fluorescent Staining of Enzymes for Flow Cytometry", Methods Cell
Biol., 33(Chap.8): 81-88, 1990

93

94

Klingel et al. "Flow Cytometric Determination of Serine Proteinase Activities in
Living Cells With Rhodamine 1 10 Substrates", Methods Cell Biol., 41(Chap.29):
449-460, 1994.

95

Malin-Berdel et al. "Flow Cytometric Determination of Esterase and Phosphatase
Activities and Kinetics in Hematopoietic Cells With Fluorogenic Substrates",
Cytometry, 1(3): 222-228, 1980.

96

Nooter et al. "On-Line Flow Cytometry. A Versatile Method for Kinetic
Measurement", Methods Cell Biol., 41(Chap.32): 509-526, 1994.

97

Turek et al. "Leucine Aminopeptidase Activity by Flow Cytometry", Methods Cell
Biol., 41(Chap.3Q): 461-468, 1994.

98

Watson et al. "Enzyme Kinetics", Methods Cell Biol., 41: 469-508, 1994.

99

Bedner et al. "Enzyme Kinetic Reactions and Fluorochrome Uptake Rates Measured
in Individual Cells by Laser Scanning Cytometry", Cytometry, 33(1): 1-9, 1998.
Abstract, P.2, Col.l, §4 - Col.2, §1, P.8, Col.2, §2.

100

Sunray et al. "Cell Activation Influences Cell Staining Kinetics", Spectrochimica Part
A, 53: 1645-1653, 1997.

101

Eisenthal et al. "Infection of K562 Cells With Influenza A Virus Increases Their
Susceptibility to Natural Killer Lysis", Pathobiology, 65: 331-340, 1997.

102

Deutsch et al. "Apparatus for High-Precision Repetitive Sequential Optical
Measurement of Living Cells", Cytometry, 16:214-226, 1994.

103

Sunray et al. "Determination of the Michaelis-Menten Constant (Km) of Intracellular
Enzymatic Reaction for Individual Live Lymphocytes", Cytometry Supplement, 10:
68-69, & The XX Congress of the International Society for Analytical Cytology,
Montpellier, F, 2000.

104

Darzynkiewicz et al. "Laser- Scanning Cytometry: A New Instrumentation With
Many Applications", Experimental Cell Research, 249(1): 1-12, 1999. Abstract, P.2,
Col.2, §4 - P.4, Col.2, §2, P.8, Col.l, §1 - Col.2, §2.

105

Sunray et al. "The Trace and Subgrouping of Lymphocyte Activation by Dynamic
Fluorescence Intensity and Polarization Measurements", Biochemical and
Biophysical Research Communications, 261(3): 712-719, 1999. Abstract, P.713,
Col.l, §5, Col.2, §7 - P.714, Col.2, §1.

106

Sunray et al. "Determination of Individual Cell Michaelis-Menten Constants",
Cytometry, 47(1): 8-16, 2002.

107

Dive et al. "Improved Methodology for Intracellular Enzyme Reaction and Inhibition
Kinetics by Flow Cytometry", Cytometry Journal of Society for Analytical Cytology,
8(6): 552-561, 1987.

EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
considered, include copy of this form with next communication to applicant.

. Applicant's unique citation designation number (optional). 2 . Applicant is to place a check mark here if English language Translation is attached.

This collection of information is required by 37 CFR 1.97 and 1 .98. The information is required to obtain or retain a benefit by the public which is to file (and by the

USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. this collection is estimated to take 2 hours to complete, including

gathering, preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount

of time you require to complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, U.S. Patent and Trademark Office,

U.S. Department of commerce, P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS.

SEND TO: Commissioner for Patents, P.O. Box 1450, Alexandria, VA 22313-1450.

If you need assistance in completing the form, call 1-800-PTO-9199 and select option 2.

PTO/SB/08b (08-03)
Approved for use through 06/30/2006. OMB 065 1 -003 1
U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE

Substitute for form 1 449A/PTO

SUPPLEMENTAL INFORMATION
DISCLOSURE
STATEMENT BY APPLICANT

{use as many sheets as necessary)

Complete if Known

Application Number

lU/JOl ,OJ7

Filing Date

June 05, 2006

First Named Inventor

Mordechai DEUTSCH et al

Group Art Unit

1744

Examiner Name

Not yet Assigned

Sheet 5 of 5

Attorney Docket Number

30024

OTHER PRIOR ART - NON PATENT LITERATURE DOCUMENTS

Examiner
Initials

Cite
No. 1

Include name of the author (in CAPITAL LETTERS), title of the article (when appropriate), title of the
item (book, magazine, journal, serial symposium, catalog, etc.) date, page(s), volume-issue number(s),
publisher, city and/or country where published.

108

Lansing Taylor et al. "Real-Time Molecular and Cellular Analysis: The New Frontier
of Drug Discovery", Current Opinion in Biotechnology, 12: 75-81, 2001.

109

Aplin et al. " Protein-Derivatised Glass Coverslips for the Study of Cell-to-
Substratum Adhesion", Analytical Biochemistry, 113: 144-148, 1981.

110

Burlage et al. "Living Biosensors for the Management and Manipulation of Microbial
Consortia",Annual. Rev. Microbiol., 48: 291-309, 1994.

111

Mrksich et al. "Using Self-Assembled Monolayers to Understand the Interactions of
Man-Made Surfaces With Proteins and Cells", Annual Reviews in Biophysics and
Biomolecular Structure, 25: 55-78, 1996.

112

Singhvi et al. "Engineering Cell Shape and Function", Science, 264: 696-698, 1994.

113

Riedel et al. "Arxula Adeninivorans Based Sensor for the Estimation of Bod",
Analytical Letters, 3 1(1): 1-12, 1998.

114

Simonian et al. "Microbial Biosensors Based on Potentiometric Detection", Methods
in Biotechnology,6, chapter 17: 237-248, 1998.

115

Arikawa et al. "Microbial Biosensors Based on Respiratory Inhibition", Methos in
Biotehnology,6, chapter 16: 225-235, 1998.

116

Yamamura et al. "Single-Cell Microarray for Analyzing Cellular Response",
Analytical Chemistry, 77(24): 8050-8056, 2005.

Signature

Considered

•EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
considered. Include copy of this form with next communication to applicant.

. Applicant's unique citation designation number (optional). 2 . Applicant is to place a check mark here if English language Translation is attached.

This collection of information is required by 37 CFR 1.97 and 1 .98. The information is required to obtain or retain a benefit by the public which is to file (and by the

USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. this collection is estimated to take 2 hours to complete, including

gathering, preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount

of time you require to complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, U.S. Patent and Trademark Office,

U.S. Department of commerce, P.O. Box 1450, Alexandria, VA 2231 3-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS.

SEND TO: Commissioner for Patents, P.O. Box 1450, Alexandria, VA 22313-1450.

If you need assistance in completing the form, call 1-800-PTO-9199 and select option 2.